A genome-wide meta-analysis uncovers six sequence variants conferring risk of vertigo.

ABSTRACT: Vertigo is the leading symptom of vestibular disorders and a major risk factor for falls. In a genome-wide association study of vertigo (N_cases = 48,072, N_controls = 894,541), we uncovered an association with six common sequence variants in individuals of European ancestry, including missense variants in ZNF91, OTOG, OTOGL, and TECTA, and a cis-eQTL for ARMC9. The association of variants in ZNF91, OTOGL, and OTOP1 was driven by an association with benign paroxysmal positional vertigo. Using previous reports of sequence variants associating with age-related hearing impairment and motion sickness, we found eight additional variants that associate with vertigo. Although disorders of the auditory and the vestibular system may co-occur, none of the six genome-wide signific

SUBMITTER: Skuladottir AT 

PROVIDER: S-EPMC8497462 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature