Variant-Specific IgA Protects Against Omicron Infection.

ABSTRACT:

Background

The emergence of rapidly evolving severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, coupled with waning vaccine-induced immunity, has contributed to the rise of vaccine breakthrough infections. It is crucial to understand how vaccine-induced protection is mediated.

Methods

We examined 2 prospective cohorts of mRNA vaccinated and boosted individuals during the Omicron wave of infection in Singapore.

Results

We found that individuals who remain uninfected over the follow-up period had a higher variant-specific IgA, but not IgG, antibody response at 1 month after booster vaccination, compared with individuals who became infected.

Conclusions

We conclude that IgA may have a potential contributory role in protection against Omicron in

SUBMITTER: Goh YS 

PROVIDER: S-EPMC11326848 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature