Elevated Exposure to Air Pollutants Accelerates Primary Glomerular Disease Progression.

ABSTRACT:

Introduction

Environmental contributors to kidney disease progression remain elusive. We explored how residential air pollution affects disease progression in patients with primary glomerulopathies.

Methods

Nephrotic Syndrome Study Network (NEPTUNE) and CureGlomerulonephropathy (CureGN) participants with residential census tract data and ≥2 years of follow-up were included. Using Cox proportional hazards models, the associations per doubling in annual average baseline concentrations of total particulate matter with diameter ≤2.5 μm (PM_2.5) and its components, black carbon (BC), and sulfate, with time to ≥40% decline in estimated glomerular filtration rate (eGFR) or kidney failure were estimated. Serum tumour necrosis factor levels and kidney tissue transcriptomic

SUBMITTER: Troost JP 

PROVIDER: S-EPMC11328569 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature