A comprehensive analysis of TRP-related gene signature, and immune infiltration in patients with colorectal cancer.

ABSTRACT:

Background

Transient receptor potential (TRP) channels are involved in the development and progression of tumors. However, their role in colorectal cancer (CRC) remains unclear, and this study aims to investigate the role of TRP-related genes in CRC.

Methods

Data was obtained from The Cancer Genome Atlas (TCGA) database, and analyses were conducted on the GSE14333 and GSE38832 datasets to assess the prognosis and mark TRP-related genes (TRGs). Subsequently, clustering analysis and immune infiltration analysis were performed to explore the relevant TRGs. In vitro validation of key TRGs' gene and protein expression was conducted using human colon cancer cells.

Results

Compared to normal tissues, 8 TRGs were significantly upregulated in CRC, while 11 were downregulated.

SUBMITTER: Liu Y 

PROVIDER: S-EPMC11330954 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature