Alterations in cardiac contractile and regulatory proteins contribute to age-related cardiac dysfunction in male rats.

ABSTRACT: Aging is associated with cardiac contractile abnormalities, but the etiology of these contractile deficits is unclear. We hypothesized that cardiac contractile and regulatory protein expression is altered during aging. To investigate this possibility, left ventricular (LV) lysates were prepared from young (6 months) and old (24 months) Fischer344 rats. There are no age-related changes in SERCA2 expression or phospholamban phosphorylation. Additionally, neither titin isoform expression nor phosphorylation differed. However, there is a significant increase in β-isoform of the myosin heavy chain (MyHC) expression and phosphorylation of TnI and MyBP-C during aging. In permeabilized strips of papillary muscle, force and Ca²⁺ sensitivity are reduced during aging, consistent with the i

SUBMITTER: Han YS 

PROVIDER: S-EPMC11338742 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature