Updated therapeutic options for human brucellosis: A systematic review and network meta-analysis of randomized controlled trials.

ABSTRACT: In clinical practice guidelines, there is no consensus about the medications that should be initially offered to patients with brucellosis. To provide informative evidence, we compared and ranked brucellosis medications based on their efficacy and safety. For this systematic review and network meta-analysis, we searched 4 English databases and 3 Chinese databases, from the date of database inception to December 13, 2023. We included randomized controlled trials (RCTs) involving children and adolescents with brucellosis, comparing different antibiotic regimens. We excluded studies explicitly targeting patients with spondylitis brucellosis, endocarditis brucellosis, and neuro-brucellosis. The primary outcomes were overall failure (efficacy) and side effects (safety). Secondary outcomes were

SUBMITTER: Huang S 

PROVIDER: S-EPMC11340890 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature