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Transcriptional regulation of photoreceptor development and homeostasis in the mammalian retina.

ABSTRACT: In the developing vertebrate retina, diverse neuronal subtypes originate from multipotent progenitors in a conserved order and are integrated into an intricate laminated architecture. Recent progress in mammalian photoreceptor development has identified a complex relationship between six key transcription-regulatory factors (RORbeta, OTX2, NRL, CRX, NR2E3 and TRbeta2) that determine rod versus M cone or S cone cell fate. We propose a step-wise 'transcriptional dominance' model of photoreceptor cell fate determination, with the S cone representing the default state of a generic photoreceptor precursor. Elucidation of gene-regulatory networks that dictate photoreceptor genesis and homeostasis will have wider implications for understanding the development of nervous system function and for the treatment of neurodegenerative diseases.

SUBMITTER: Swaroop A

PROVIDER: S-EPMC11346175 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature

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Transcriptional regulation of photoreceptor development and homeostasis in the mammalian retina.

Swaroop Anand A Kim Douglas D Forrest Douglas D

Nature reviews. Neuroscience 20100801 8

In the developing vertebrate retina, diverse neuronal subtypes originate from multipotent progenitors in a conserved order and are integrated into an intricate laminated architecture. Recent progress in mammalian photoreceptor development has identified a complex relationship between six key transcription-regulatory factors (RORbeta, OTX2, NRL, CRX, NR2E3 and TRbeta2) that determine rod versus M cone or S cone cell fate. We propose a step-wise 'transcriptional dominance' model of photoreceptor c ...[more]

PMID: 20648062

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2025-08-18 | GSE278881 | GEO

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