Ngfr⁺ cholinergic projection from SI/nBM to mPFC selectively regulates temporal order recognition memory.

ABSTRACT: Acetylcholine regulates various cognitive functions through broad cholinergic innervation. However, specific cholinergic subpopulations, circuits and molecular mechanisms underlying recognition memory remain largely unknown. Here we show that Ngfr⁺ cholinergic neurons in the substantia innominate (SI)/nucleus basalis of Meynert (nBM)-medial prefrontal cortex (mPFC) circuit selectively underlies recency judgements. Loss of nerve growth factor receptor (Ngfr^-/- mice) reduced the excitability of cholinergic neurons in the SI/nBM-mPFC circuit but not in the medial septum (MS)-hippocampus pathway, and impaired temporal order memory but not novel object and object location recognition. Expression of Ngfr in Ngfr^-/- SI/nBM restored defected temporal order memory.

SUBMITTER: Mei F 

PROVIDER: S-EPMC11347598 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature