Catecholaminergic Modulation of Metacontrol Is Reflected by Changes in Aperiodic EEG Activity.

ABSTRACT:

Background

"Metacontrol" describes the ability to maintain an optimal balance between cognitive control styles that are either more persistent or more flexible. Recent studies have shown a link between metacontrol and aperiodic EEG patterns. The present study aimed to gain more insight into the neurobiological underpinnings of metacontrol by using methylphenidate (MPH), a compound known to increase postsynaptic catecholamine levels and modulate cortical noise.

Methods

In a double-blind, randomized, placebo-controlled study design, we investigated the effect of MPH (0.5 mg/kg) on aperiodic EEG activity during a flanker task in a sample of n = 25 neurotypical adults. To quantify cortical noise, we employed the fitting oscillations and one over f algorithm.

Results

Compa

SUBMITTER: Gao Y 

PROVIDER: S-EPMC11348007 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature