Mendelian randomization study of urolithiasis: exploration of risk factors using human blood metabolites.

ABSTRACT:

Background

Urolithiasis is a highly prevalent global disease closely associated with metabolic factors; however, the causal relationship between blood metabolites and urolithiasis remains poorly understood.

Method

In our study, we employed a bi-directional two-sample Mendelian randomization (MR) analysis to investigate the causal associations between urolithiasis and metabolites. The random-effects inverse-variance weighted (IVW) estimation method was utilized as the primary approach, complemented by several other estimators including MR-Egger, weighted median, colocalization and MR-PRESSO. Furthermore, the study included replication and meta-analysis. Finally, we conducted metabolic pathway analysis to elucidate potential metabolic pathways.

Results

After conducting

SUBMITTER: Hu D 

PROVIDER: S-EPMC11350957 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature