TAAR8 Mediates Increased Migrasome Formation by Cadaverine in RPE Cells.

ABSTRACT: Migrasomes, the newly discovered cellular organelles that form large vesicle-like structures on the retraction fibers of migrating cells, are thought to be involved in communication between neighboring cells, cellular content transfer, unwanted material shedding, and information integration. Although their formation has been described previously, the molecular mechanisms of migrasome biogenesis are largely unknown. Here, we developed a cell line that overexpresses GFP-tetraspanin4, enabling observation of migrasomes. To identify compounds that regulate migrasome activity in retinal pigment epithelial (RPE) cells, we screened a fecal chemical library and identified cadaverine, a biogenic amine, as a potent migrasome formation inducer. Compared with normal migrating cells, those treated with

SUBMITTER: Kim JB 

PROVIDER: S-EPMC11352285 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature