Identification of Schizophrenia Susceptibility Loci in the Urban Taiwanese Population.

ABSTRACT: Background and Objectives: Genomic studies have identified several SNP loci associated with schizophrenia in East Asian populations. Environmental factors, particularly urbanization, play a significant role in schizophrenia development. This study aimed to identify schizophrenia susceptibility loci and characterize their biological functions and molecular pathways in Taiwanese urban Han individuals. Materials and Methods: Participants with schizophrenia were recruited from the Taiwan Precision Medicine Initiative at Tri-Service General Hospital. Genotype-phenotype association analysis was performed, with significant variants annotated and analyzed for functional relevance. Results: A total of 137 schizophrenia patients and 26,129 controls were enrolled. Ten significant

SUBMITTER: Huang CC 

PROVIDER: S-EPMC11356138 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature