Causal associations between insulin and Lp(a) levels in Caucasian population: a Mendelian randomization study.

ABSTRACT:

Background

Numerous observational studies have demonstrated that circulating lipoprotein(a) [Lp(a)] might be inversely related to the risk of type 2 diabetes (T2D). However, recent Mendelian randomization (MR) studies do not consistently support this association. The results of in vitro research suggest that high insulin concentrations can suppress Lp(a) levels by affecting apolipoprotein(a) [apo(a)] synthesis. This study aimed to identify the relationship between genetically predicted insulin concentrations and Lp(a) levels, which may partly explain the associations between low Lp(a) levels and increased risk of T2D.

Methods

Independent genetic variants strongly associated with fasting insulin levels were identified from meta-analyses of genome-wide association studies in E

SUBMITTER: Lejawa M 

PROVIDER: S-EPMC11360791 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature