Identification of variables and development of a prediction model for DIBH eligibility in left-sided breast cancer radiotherapy: a prospective cohort study with temporal validation.

ABSTRACT:

Objective

To identify variables associated with a patients' ability to reproducibly hold their breath for deep-inspiration breath-hold (DIBH) radiotherapy (RT) and to develop a predictive model for DIBH eligibility.

Methods

This prospective, single-institution, IRB-approved observational study included women with left-sided breast cancer treated between January 2023 and March 2024. Patients underwent multiple breath-hold sessions over 2-3 consecutive days. DIBH waveform metrics and clinical factors were recorded and analysed. Logistic mixed modelling was used to predict DIBH eligibility, and a temporal validation cohort was used to assess model performance.

Results

In total, 253 patients were included, with 206 in the model development cohort and 47 in the temporal va

SUBMITTER: Ahmad I 

PROVIDER: S-EPMC11363400 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature