Association between high-density lipoprotein and functional outcome of ischemic stroke patients in a Taiwanese population.

ABSTRACT: Despite recent findings indicating a paradoxical association between high-density lipoprotein cholesterol (HDL-C) levels and cardiovascular disease (CVD) mortality, the impact of HDL-C on subsequent outcomes after ischemic stroke remains unclear. The study aims to investigate the relationships between HDL-C levels and post-stroke functional outcomes while examining the potential modifying influence of HDL-C-related single nucleotide polymorphisms identified through genome-wide association studies. This cohort study included 1,310 patients diagnosed with acute ischemic stroke (AIS), all of whom had their admission serum lipid profile and genotyping information. Participants were categorized into four groups based on gender and HDL-C level. Prognostic outcomes were assessed using a modified

SUBMITTER: Lin TC 

PROVIDER: S-EPMC11363607 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature