Low power supercycled TPPM decoupling.

ABSTRACT: Improving the spectral sensitivity and resolution of biological solids is one of the long-standing problems in nuclear magnetic resonance (NMR) spectroscopy. In this report, we introduce low-power supercycled variants of two-pulse phase-modulated (TPPM) sequence for heteronuclear decoupling. The utility of the sequence is shown by improvements in the transverse relaxation time of observed nuclei (with ¹H decoupling) with its application to different samples (uniformly ¹³C, ¹⁵N, ²H-labeled GB1 back-exchanged with 25% H₂O and 75% D₂O, uniformly ¹³C, ¹⁵N, ²H-labeled human derived Asyn fibril back-exchanged with 100% H₂O and uniformly ¹³C, ¹⁵N -labeled human deriv

SUBMITTER: Garg R 

PROVIDER: S-EPMC11364148 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature