Joint and interactive associations of body mass index and genetic factors with cardiovascular disease: a prospective study in UK Biobank.

ABSTRACT:

Background

Both body mass index (BMI) and genetic factors independently contribute to cardiovascular disease (CVD). However, it is unclear whether genetic risk modifies the association between BMI and the risk of incident CVD. This study aimed to investigate whether BMI categories and genetic risk jointly and interactively contribute to incident CVD events, including hypertension (HTN), atrial fibrillation (AF), coronary heart disease (CHD), stroke, and heart failure (HF).

Methods

A total of 496,851 participants from the UK Biobank with one or more new-onset CVD events were included in the analyses. BMI was categorized as normal weight (< 25.0 kg/m²), overweight (25.0-29.9 kg/m²), and obesity (≥ 30.0 kg/m²). Genetic risk for each outcome was

SUBMITTER: Huang R 

PROVIDER: S-EPMC11367834 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature