Antivirals for treatment of severe influenza: a systematic review and network meta-analysis of randomised controlled trials.

ABSTRACT:

Background

The optimal antiviral drug for treatment of severe influenza remains unclear. To support updated WHO influenza clinical guidelines, this systematic review and network meta-analysis evaluated antivirals for treatment of patients with severe influenza.

Methods

We systematically searched MEDLINE, Embase, Cochrane Central Register of Controlled Trials, Cumulative Index to Nursing and Allied Health Literature, Global Health, Epistemonikos, and ClinicalTrials.gov for randomised controlled trials published up to Sept 20, 2023, that enrolled hospitalised patients with suspected or laboratory-confirmed influenza and compared direct-acting influenza antivirals against placebo, standard care, or another antiviral. Pairs of coauthors independently extracted data on study char

SUBMITTER: Gao Y 

PROVIDER: S-EPMC11369965 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature