3D-Printed Phenylboronic Acid-Bearing Hydrogels for Glucose-Triggered Drug Release.

ABSTRACT: Diabetes is a major health concern that the next-generation of on-demand insulin releasing implants may overcome via personalized therapy. Therein, 3D-printed phenylboronic acid-containing implants with on-demand glucose-triggered drug release abilities are produced using high resolution stereolithography technology. To that end, the methacrylation of phenylboronic acid is targeted following a two-step reaction. The resulting photocurable phenylboronic acid derivative is accordingly incorporated within bioinert polyhydroxyethyl methacrylate-based hydrogels at varying loadings. The end result is a sub-centimeter scaled 3D-printed bioinert implant that can be remotely activated with 1,2-diols and 1,3-diols such as glucose for on-demand drug administration such as insulin. As a proof of conce

SUBMITTER: Odent J 

PROVIDER: S-EPMC11398034 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature