Upregulated SKP2 Empowers Epidermal Proliferation Through Downregulation of P27 Kip1.

ABSTRACT:

Background

Excessive growth of keratinocytes is the critical event in the etiology of psoriasis. However, the underlying molecular mechanism of psoriatic keratinocyte hyperproliferation is still unclear.

Objective

This study aimed to figure out the potential contributory role of S-phase kinase-associated protein 2 (SKP2) in promoting the hyperproliferation of keratinocytes in psoriasis.

Methods

We analyzed microarray data (GSE41662) to investigate the gene expression of SKP2 in psoriatic lesion skins compared with their adjacent non-lesional skin. Then, we further confirmed the mRNA and protein expression of SKP2 in human psoriatic skin tissues, imiquimod (IMQ)-induced psoriatic mice back skins and tumor necrosis factor α (TNF-α), interleukin (IL)-17A and IL-6-

SUBMITTER: Tang L 

PROVIDER: S-EPMC11439983 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature