Genomic epidemiology describes introduction and outbreaks of antifungal drug-resistant <i>Candida auris</i>.

ABSTRACT: Candida auris is a globally emerged fungal pathogen causing nosocomial invasive infections. Here, we use cutting-edge genomic approaches to elucidate the temporal and geographic epidemiology of drug-resistant C. auris within the UK. We analysed a representative sample of over 200 isolates from multiple UK hospitals to assess the number and timings of C. auris introductions and infer subsequent patterns of inter- and intra-hospital transmission of azole drug-resistant isolates. We identify at least one introduction from Clade I and two from Clade III into the UK, and observe temporal and geographical evidence for multiple transmission events of antifungal drug resistant isolates between hospitals and identified local within-hospital patient-to-patient transmission event

SUBMITTER: Kappel D 

PROVIDER: S-EPMC11442302 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature