Exploring the circulating metabolome of sepsis: metabolomic and lipidomic profiles sampled in the ambulance.

ABSTRACT:

Background

Sepsis is defined as a dysfunctional host response to infection. The diverse clinical presentations of sepsis pose diagnostic challenges and there is a demand for enhanced diagnostic markers for sepsis as well as an understanding of the underlying pathological mechanisms involved in sepsis. From this perspective, metabolomics has emerged as a potentially valuable tool for aiding in the early identification of sepsis that could highlight key metabolic pathways and underlying pathological mechanisms.

Objective

The aim of this investigation is to explore the early metabolomic and lipidomic profiles in a prospective cohort where plasma samples (n = 138) were obtained during ambulance transport among patients with infection according to clinical judgement who subsequen

SUBMITTER: Salihovic S 

PROVIDER: S-EPMC11455889 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature