Biopolymer Nano-Network for Antimicrobial Peptide Protection and Local Delivery.

ABSTRACT: Antimicrobial resistance (AMR) develops when bacteria no longer respond to conventional antimicrobial treatment. The limited treatment options for resistant infections result in a significantly increased medical burden. Antimicrobial peptides offer advantages for treatment of resistant infections, including broad-spectrum activity and lower risk of resistance development. However, sensitivity to proteolytic cleavage often limits their clinical application. Here, a moldable and biodegradable colloidal nano-network is presented that protects bioactive peptides from enzymatic degradation and delivers them locally. An antimicrobial peptide, PA-13, is encapsulated electrostatically into positively and negatively charged nanoparticles made of chitosan and dextran sulfate without requiring chemic

SUBMITTER: Klubthawee N 

PROVIDER: S-EPMC11468357 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature