Amphiphilic Copolymers for Versatile, Facile, and In Situ Tunable Surface Biofunctionalization.

ABSTRACT: Precision surface engineering is key to advanced biomaterials. A new platform of PEGylated styrene-maleic acid copolymers for adsorptive surface biofunctionalization is reported. Balanced amphiphilicity renders the copolymers water-soluble but strongly affine for surfaces. Fine-tuning of their molecular architecture provides control over adsorptive anchorage onto specific materials-which is why they are referred to as "anchor polymers" (APs)-and over structural characteristics of the adsorbed layers. Conjugatable with an array of bioactives-including cytokine-complexing glycosaminoglycans, cell-adhesion-mediating peptides and antimicrobials-APs can be applied to customize materials for demanding biotechnologies in uniquely versatile, simple, and robust ways. Moreover, homo- and heterodispl

SUBMITTER: Ruland A 

PROVIDER: S-EPMC11468472 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature