Miniaturized Capsule System Toward Real-Time Electrochemical Detection of H₂ S in the Gastrointestinal Tract.

ABSTRACT: Hydrogen sulfide (H₂ S) is a gaseous inflammatory mediator and important signaling molecule for maintaining gastrointestinal (GI) homeostasis. Excess intraluminal H₂ S in the GI tract has been implicated in inflammatory bowel disease and neurodegenerative disorders; however, the role of H₂ S in disease pathogenesis and progression is unclear. Herein, an electrochemical gas-sensing ingestible capsule is developed to enable real-time, wireless amperometric measurement of H₂ S in GI conditions. A gold (Au) three-electrode sensor is modified with a Nafion solid-polymer electrolyte (Nafion-Au) to enhance selectivity toward H₂ S in humid environments. The Nafion-Au sensor-integrated capsule shows a linear current response in H₂ S

SUBMITTER: Stine JM 

PROVIDER: S-EPMC11468942 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature