Dual-Crosslinked Dynamic Hydrogel Incorporating {Mo₁₅₄ } with pH and NIR Responsiveness for Chemo-Photothermal Therapy.

ABSTRACT: Polyoxometalates are an emerging class of molecular clusters, with well-defined structures and chemical compositions that are produced through simple, low-cost, and highly reproducible methods. In particular, the wheel-shaped cluster {Mo₁₅₄ } is a promising photothermal agent due to its intervalence charge transfer transitions. However, its toxicity hinders its systemic administration, being the development of a localized delivery system still incipient. Herein, an injectable and self-healing hydrogel of easy preparation and administration is developed, incorporating both {Mo₁₅₄ } and doxorubicin for synergistic photothermal and chemotherapy applications. The hydrogel is composed of benzylaldehyde functionalized polyethylene glycol, poly(N-isopropylacrylamide) functio

SUBMITTER: Guedes G 

PROVIDER: S-EPMC11468987 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature