On-demand controlled bidirectional DNAzyme path for ultra-sensitive heavy metal ion detection.

ABSTRACT: A bidirectional self-powered biosensor is constructed for the quasi-simultaneous detection of Pb²⁺ and Hg²⁺ based on MoS₂@CuS heterostructures as an accelerator and hybridization chain reaction (HCR) as a signal amplification strategy. MoS₂@CuS heterostructures significantly facilitate electron transfer between glucose and bioelectrodes, thereby greatly improving the detection signal of self-powered biosensors. This novel biosensor employs the unique sequences of DNAzymes to isolate Pb²⁺ and Hg²⁺ by the cleavage effect and thymine (T)-Hg²⁺-thymine (T) structures, respectively. In the process, Pb²⁺ cuts the sequence of DNAzyme at the bioanode to trigger glucose oxidation to monitor Pb²⁺. The a

SUBMITTER: Xu J 

PROVIDER: S-EPMC11474792 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature