Association of preoperative to postoperative change in cerebrospinal fluid fibrinogen with postoperative delirium.

ABSTRACT:

Background

We aimed to assess perioperative changes in fibrinogen in the cerebrospinal fluid (CSF), their association with markers of blood-brain barrier breakdown and neuroinflammation, and their association with postoperative delirium severity.

Methods

We conducted a secondary analysis of the Interventions for Postoperative Delirium-Biomarker 2 (IPOD-B2, NCT02926417) study, a prospective observational cohort study. We included 24 patients aged >21 yr undergoing aortic aneurysm repair. CSF samples were obtained before (n=24) and after surgery (n=13), with some participants having multiple postoperative samples. Our primary outcome was the perioperative change in CSF fibrinogen. Delirium was assessed using the Delirium Rating Scale-Revised-98.

Results

CS

SUBMITTER: Payne T 

PROVIDER: S-EPMC11490679 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature