FgUbiH Is Essential for Vegetative Development, Energy Metabolism, and Antioxidant Activity in <i>Fusarium graminearum</i>.

ABSTRACT: Fusarium head blight in wheat is mainly caused by Fusarium graminearum and results in significant economic losses. Coenzyme Q (CoQ) is ubiquitously produced across organisms and functions as a hydrogen carrier in energy metabolism. While UbiH in Escherichia coli serves as a hydroxylase in CoQ biosynthesis, its role in phytopathogenic fungi is not well understood. This study explored the role of the hydroxylase FgUbiH in F. graminearum. Using a FgUbiH deletion mutant, we observed reduced hyphal growth, conidial production, germination, toxin synthesis, and pathogenicity compared to the wild-type. A transcriptome analysis indicated FgUbiH's involvement in regulating carbohydrate and amino acid metabolism. Deletion of FgUbiH impaired mitochondrial fun

SUBMITTER: Ge J 

PROVIDER: S-EPMC11509934 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature