Intact NOX2 in T Cells Mediates Pregnancy-Induced Renal Damage in Dahl SS Rats.

ABSTRACT:

Background

Hypertensive disorders of pregnancy are associated with increased risk for cardiovascular disease, renal disease, and mortality. While the exact mechanisms remain unclear, T cells and reactive oxygen species have been implicated in its pathogenesis. We utilized Dahl salt-sensitive (SS), SS^CD247-/- (Dahl SS CD247 knockout rat; lacking T cells), and SS^p67phox-/- (Dahl SS p67^phox [NOX2 (NADPH [nitcotinamide adenine dinucleotide phosphate] oxidase 2)] knockout rat; lacking NOX2) rats to investigate these mechanisms in primigravida and multigravida states.

Methods

We assessed blood pressure and renal damage phenotypes in SS, SS^CD247-/-, and SS^p67phox-/- rats during primigravida and multigravida states. To investiga

SUBMITTER: Dasinger JH 

PROVIDER: S-EPMC11517830 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature