Cancer and lymphatic marker FOXC2 drives wound healing and fibrotic tissue formation.

ABSTRACT:

Introduction

The FOXC2 transcription factor has been tied to a wide range of disease states, serving as a promising prognostic biomarker associated with aggressive basal-like human breast cancers (increased cancer invasion and metastasis). Dysregulation of FOXC2 expression has also been found to promote defects in lymphatic remodeling and hyperplastic lymphedema-distichiasis (LD). Since chronic lymphedema is a forerunner of several malignancies and cancers have been known to arise from poorly healing chronic wounds (e.g., Marjolin ulcers), we examined the effect of Foxc2 dysfunction on skin wound healing.

Methods

We used our splinted excisional wounding model that mimics human-like wound healing on wildtype and Foxc2^+/- mice (n = 4), which demonstrate incomplete l

SUBMITTER: Granoski MB 

PROVIDER: S-EPMC11518795 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature