Analysis of early-pregnancy metabolome in early- and late-onset gestational diabetes reveals distinct associations with maternal overweight.

ABSTRACT:

Aims/hypothesis

It is not known whether the early-pregnancy metabolome differs in patients with early- vs late-onset gestational diabetes mellitus (GDM) stratified by maternal overweight. The aims of this study were to analyse correlations between early-pregnancy metabolites and maternal glycaemic and anthropometric characteristics, and to identify early-pregnancy metabolomic alterations that characterise lean women (BMI <25 kg/m²) and women with overweight (BMI ≥25 kg/m²) with early-onset GDM (E-GDM) or late-onset GDM (L-GDM).

Methods

We performed a nested case-control study within the population-based prospective Early Diagnosis of Diabetes in Pregnancy cohort, comprising 210 participants with GDM (126 early-onset, 84 late-onset) and 209 normoglycaemi

SUBMITTER: Masalin S 

PROVIDER: S-EPMC11519293 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature