Protective effect of TCR-mediated MAIT cell activation during experimental autoimmune encephalomyelitis.

ABSTRACT: Mucosal-associated invariant T (MAIT) cells express semi-invariant T cell receptors (TCR) for recognizing bacterial and yeast antigens derived from riboflavin metabolites presented on the non-polymorphic MHC class I-related protein 1 (MR1). Neuroinflammation in multiple sclerosis (MS) is likely initiated by autoreactive T cells and perpetuated by infiltration of additional immune cells, but the precise role of MAIT cells in MS pathogenesis remains unknown. Here, we use experimental autoimmune encephalomyelitis (EAE), a mouse model of MS, and find an accumulation of MAIT cells in the inflamed central nervous system (CNS) enriched for MAIT17 (RORγt⁺) and MAIT1/17 (T-bet⁺RORγt⁺) subsets with inflammatory and protective features. Results from transcriptome prof

SUBMITTER: Walkenhorst M 

PROVIDER: S-EPMC11519641 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature