Maternal NO₂ exposure and fetal growth restriction: Hypoxia transmission and lncRNAs-proinflammation-mediated abnormal hematopoiesis.

ABSTRACT: Epidemiological studies show a strong correlation between air pollution and fetal growth restriction (FGR), but existing results are controversial due to inherent limitations, such as causality of specific pollutants, developmental origin, and maternal-fetal transmission. To address this controversy, we first conducted a retrospective analysis of 28,796 newborns and revealed that maternal nitrogen dioxide (NO₂) exposure during the second trimester was positively associated with FGR, with an adjusted odds ratio of 1.075 (95% confidence interval: 1.020-1.133) per 10 μg/m³ NO₂ increase for small for gestational age. Then, by establishing an animal model of prenatal NO₂ exposure, we confirmed its adverse effects on embryonic growth and hematopoiesis

SUBMITTER: Qin L 

PROVIDER: S-EPMC11536148 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature