Evaluation of a Burkholderia ambifaria strain from plants as a novel promising probiotic in dental caries management.

ABSTRACT:

Background

Probiotics serve as a novel preventive or therapeutic approach for dental caries owing to their ability to reverse dysbiosis and restore a healthy microbiota. Here, we identified Burkholderia ambifaria AFS098024 as a probiotic candidate isolated from plants.

Methods

The safety of B. ambifaria was evaluated by hemolytic activity, D-lactic acid production and antibiotic susceptibility. In vitro biofilm model derived from the saliva of caries-free and caries-active donors and in vivo rat caries model were used to assess the efficacy of B. ambifaria in caries prevention and treatment.

Results

B. ambifaria was safe as a probiotic candidate and it could integrate with in vitro biofilm model. It significantly reduce

SUBMITTER: Chen Z 

PROVIDER: S-EPMC11536693 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature