An injectable hyaluronic acid/lithium calcium silicate soft tissue filler with vascularization and collagen regeneration.

ABSTRACT: The significance of collagen and vascular in skin augmentation have been recognized in recent years. However, current skin tissue fillers, e.g. hyaluronic acid (HA) or HA-based hydrogel, fail to meet the perfect augmentation requirements due to their inadequate long-term support effect and the lack of tissue-inducing activity. Herein, an injectable skin filler containing hyaluronic acid (HA) hydrogel and lithium calcium silicate (LCS, Li₂Ca₄Si₄O₁₃) bioceramic microspheres was developed for skin tissue fillers, owing to the excellent biological function of silicate bioceramics. The HA-LCS fillers could be easily injected through a tiny standard medical needle (27 G) with force of less than 36 N, and showed good biocompatibility both in v

SUBMITTER: Huang J 

PROVIDER: S-EPMC11539074 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature