Ren-Shen-Bu-Qi decoction alleviates exercise fatigue through activating PI3K/AKT/Nrf2 pathway in mice.

ABSTRACT:

Background

Fatigue is a prevalent issue that can lead individuals to a sub-health condition, impacting their work efficiency and quality of life. There are limited effective treatment options available for fatigue. Ren-Shen-Bu-Qi decoction (RSBQD) is a proprietary herbal remedy that is designed to address fatigue. However, the specific pharmacological mechanisms and basis of RSBQD are not yet fully understood.

Purpose

This study aimed to investigate the pharmacological effects and mechanisms of RSBQD in a mouse model of exercise fatigue.

Materials and methods

UPLC-Q-Orbitrap HRMS was used to analyze the chemical composition of RSBQD. The pharmacological basis and molecular mechanism of RSBQD on exercise fatigue were predicted using network pharmacology analysis. Subse

SUBMITTER: Chen Y 

PROVIDER: S-EPMC11539552 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature