Stereodivergent Synthesis of Aldol Products Using Pseudo-C₂ Symmetric N-benzyl-4-(trifluoromethyl)piperidine-2,6-dione.

ABSTRACT: The present article describes the successful performance of crossed aldol reactions of the CF₃-containing pseudo-C₂ symmetric cyclic imide with various aldehydes. The utilization of HMPA as an additive attained the preferential formation of the anti-products in good to excellent yields, which contrasts with our previous method without this additive, proceeding to furnish the corresponding syn-isomers. The effective participation of ketones and α,β-unsaturated carbonyl compounds in reactions with this imide was also demonstrated to expand the application of this imide.

SUBMITTER: Yada R 

PROVIDER: S-EPMC11547649 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature