Integrative analysis of transcriptomic and immunoproteomic data reveals stress response mechanisms in Listeria monocytogenes.

ABSTRACT: Listeria monocytogenes is a significant concern in the food industry due to its association with outbreaks of listeriosis, particularly affecting vulnerable populations. High-throughput technologies such as RNA sequencing (RNA-seq) and proteomics offer valuable insights into the molecular responses of L. monocytogenes to stress environments. In this study, a combined transcriptomic and immunoproteomic approach was applied to explore the stress response mechanisms of the L. monocytogenes strain ST7, which was responsible for an outbreak in central Italy. The bacterium was exposed to both optimal conditions and a stress environment representative of pork product matrices (pH 5.5; 7 % NaCl) and thermal abuse prior to consumption (12 °C).Transcriptomic analysis revealed va

SUBMITTER: D'Onofrio F 

PROVIDER: S-EPMC11550065 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature