Highly prevalent geriatric medications and their effect on β-amyloid fibril formation.

ABSTRACT:

Background

The unprecedented increase in the older population and ever-increasing incidence of dementia are leading to a "silver tsunami" in upcoming decades. To combat multimorbidity and maintain daily activities, elderly people face a high prevalence of polypharmacy. However, how these medications affect dementia-related pathology, such as Alzheimer's β-amyloid (Aβ) fibrils formation, remains unknown. In the present study, we aimed to analyze the medication profiles of Alzheimer's disease (AD; n = 124), mild cognitive impairment (MCI; n = 114), and non-demented (ND; n = 228) patients to identify highly prevalent drugs and to determine the effects of those drugs on Aβ fibrils formation.

Methods

Study subjects (≥ 65 years) were recruited from an academic geriatric practice t

SUBMITTER: Zaman Z 

PROVIDER: S-EPMC11562802 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature