Stearoyl-CoA desaturase in CD4⁺ T cells suppresses tumor growth through activation of the CXCR3/CXCL11 axis in CD8⁺ T cells.

ABSTRACT:

Background

Within the tumor microenvironment, altered lipid metabolism promotes cancer cell malignancy by activating oncogenic cascades; however, impact of lipid metabolism in CD4⁺ tumor-infiltrating lymphocytes (TILs) remains poorly understood. Here, we elucidated that role of stearoyl-CoA desaturase (SCD) increased by treatment with cancer-associated fibroblast (CAF) supernatant in CD4⁺ T cells on their subset differentiation and activity of CD8⁺ T cells.

Results

In our study, we observed that CD4⁺ TILs had higher lipid droplet content than CD4⁺ splenic T cells. In tumor tissue, CAF-derived supernatant provided fatty acids to CD4⁺ TILs, which increased the expression of SCD and oleic acid (OA) content. Incre

SUBMITTER: Hwang SH 

PROVIDER: S-EPMC11566202 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature