Cooperative participation of CagA and NFATc1 in the pathogenesis of antibiotics-responsive gastric MALT lymphoma.

ABSTRACT:

Background

This study aimed to explore whether cytotoxin-associated gene A (CagA) can inhibit cell cycle progression by activating nuclear factor of activated T cells (NFAT) in lymphoma B cells and contribute to Helicobacter pylori eradication (HPE) responsiveness (complete remission [CR] after HPE) in gastric mucosa-associated lymphoid tissue (MALT) lymphoma.

Materials and methods

We co-cultured three B-lymphoma cell lines (MA-1, OCI-Ly3, and OCI-Ly7) with HP strains (derived from HPE-responsive gastric MALT lymphoma) and evaluated the expression patterns of CagA, phosphorylated (p)-CagA (CagA^P-Tyr), and CagA-signaling molecules, cell-cycle inhibitors, p-NFATc1 (Ser¹⁷²), and NFATc1 using western blotting. Furthermore, we evaluated the association betwe

SUBMITTER: Tsai HJ 

PROVIDER: S-EPMC11575159 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature