Cancer-associated fibroblasts reveal aberrant DNA methylation across different types of cancer.

ABSTRACT:

Background

Cancer-associated fibroblasts (CAFs) are essential components of the tumor microenvironment and play a critical role in cancer progression. Numerous studies have identified significant molecular differences between CAFs and normal tissue-associated fibroblasts (NAFs). In this study, we isolated CAFs and NAFs from liver tumors and conducted a comprehensive analysis of their DNA methylation profiles, integrating our finding with data from studies on other cancer types.

Results

Our analysis revealed that several CAF samples exhibited aberrant DNA methylation patterns, which corresponded with altered gene expression levels. Notably, DNA methylation at liver CAF-specific CpG sites was linked to survival outcomes in liver cancer datasets. An integrative analysis using p

SUBMITTER: Schmidt M 

PROVIDER: S-EPMC11580436 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature