RNA-Seq Reveals Transcriptome Changes Following Zika Virus Infection in Fetal Brains in <i>c-Flip</i> Knockdown Mice.

ABSTRACT: The FADD-like interleukin-1β converting enzyme (FLICE)-inhibitory protein (c-FLIP) plays a crucial role in various biological processes, including apoptosis and inflammation. However, the complete transcriptional profile altered by the c-FLIP is not fully understood. Furthermore, the impact of the c-FLIP deficiency on the transcriptome during a Zika virus (ZIKV) infection, which induces apoptosis and inflammation in the central nervous system (CNS), has not yet been elucidated. In this study, we compared transcriptome profiles between wild-type (WT) and the c-Flip heterozygous knockout mice (c-Flip^+/-) fetal heads at embryonic day 13.5 from control and PBS-infected WT dams mated with c-Flip^+/- sires. In the non-infected group, we observed differen

SUBMITTER: Xie T 

PROVIDER: S-EPMC11599063 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature