A nationwide cohort study of inflammatory bowel disease, histological activity and fracture risk.

ABSTRACT:

Background

Individuals with inflammatory bowel disease (IBD) are at increased risk of fracture. It is unclear if this risk varies by recent histological activity.

Aims

To determine the fracture risk in IBD during periods with and without histological inflammation.

Methods

We studied a nationwide cohort of 54,591 individuals diagnosed with IBD in 1990-2016 with longitudinal data on ileo-colorectal biopsies. Fractures were identified by inpatient and hospital-based outpatient diagnoses. We derived Cox regression estimated hazard ratios (HRs) for fracture during 12 months following a histological inflammation (vs. histological remission) record after adjusting for socio-demographics, comorbidities, IBD duration, IBD-related surgery and hospitalization. We adjusted sensit

SUBMITTER: Marild K 

PROVIDER: S-EPMC11599792 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature