Single nucleus RNA-sequencing reveals transcriptional synchrony across different relationships.

ABSTRACT: As relationships mature, partners share common goals, improve their ability to work together, and experience coordinated emotions. However, the neural underpinnings responsible for this unique, pair-specific experience remain largely unexplored. Here, we used single nucleus RNA-sequencing to examine the transcriptional landscape of the nucleus accumbens (NAc) in socially monogamous prairie voles in peer or mating-based relationships. We show that, regardless of pairing type, prairie voles exhibit transcriptional synchrony with a partner. Further, we identify genes expressed in oligodendrocyte progenitor cells that are synchronized between partners, correlated with dyadic behavior, and sensitive to partner separation. Together, our data indicate that the pair-specific social environment pro

SUBMITTER: Brusman LE 

PROVIDER: S-EPMC11601461 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature