Neuroimaging Insights into Brain Mechanisms of Early-onset Restrictive Eating Disorders.

ABSTRACT:

Background

Early-onset restrictive eating disorders (rEO-ED) encompass a heterogeneous group of conditions, including early-onset anorexia nervosa (EO-AN) and avoidant restrictive food intake disorders (ARFID). Almost nothing is known about the consequences of rEO-ED on brain development.

Methods

We performed the largest comparison of MRI-derived brain features in children and early adolescents (<13 years) with EO-AN (n=124), ARFID (n=50), and typically developing individuals (TD, n=112).

Results

Despite similar body mass index (BMI) distributions, EO-AN and ARFID showed divergent structural patterns, suggesting independent brain mechanisms. Half the regional brain measures were correlated with BMI in EO-AN and none in ARFID, indicating a partial mediation of EO-AN si

SUBMITTER: Moreau CA 

PROVIDER: S-EPMC11601758 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature