Landscape of antisense genes in the human genome and identification of new human hepatic antisense RNAs by long-read sequencing.

ABSTRACT:

Background

Protein-coding genes have been considered the functional part of the genome, although they represent only 2% of the genome. In contrast, more than 90% of the genome produces non-coding RNA (ncRNA), including antisense (AS) genes, a type of long non-coding genes (encoding transcripts > 200 nucleotides) located on the opposite strand of coding genes. Therefore, antisense RNA (asRNA) can be complementary to the counterpart sense RNA, supporting a regulatory role with potential pathogenic consequences, as their deregulation has been associated with cardiovascular disease, cancer, and diabetes.

Results

We performed an in-depth review of AS genes in Ensembl and evaluated the expression of AS genes in human liver by third-generation RNA sequencing methods. Currently, 165

SUBMITTER: Rojo-Carrillo JJ 

PROVIDER: S-EPMC11603882 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature