Solvent extraction of Ac-225 in nano-layer coated, solvent resistant PDMS microfluidic chips.

ABSTRACT: Separating medical radionuclides from their targets is one of the most critical steps in radiopharmaceutical production. Among many separation methods, solvent extraction has a lot of potential due to its simplicity, high selectivity, and high efficiency. Especially with the rise of polydimethylsiloxane (PDMS) microfluidic chips, this extraction process can take place in a simple and reproducible chip platform continuously and automatically. Furthermore, the microfluidic chips can be coated with metal-oxide nano-layers, increasing their resistance against the employed organic solvents. We fabricated such chips and demonstrated a parallel flow at a considerably large range of flow rates using the aqueous and organic solutions commonly used in medical radionuclide extraction. In our followin

SUBMITTER: Trapp S 

PROVIDER: S-EPMC11612499 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature