BioDolphin as a comprehensive database of lipid-protein binding interactions.

ABSTRACT: Lipid-protein interactions are crucial for virtually all biological processes in living cells. However, existing structural databases focusing on these interactions are limited to integral membrane proteins. A systematic understanding of diverse lipid-protein interactions also encompassing lipid-anchored, peripheral membrane and soluble lipid binding proteins remains to be elucidated. To address this gap and facilitate the research of universal lipid-protein assemblies, we developed BioDolphin - a curated database with over 127,000 lipid-protein interactions. BioDolphin provides comprehensive annotations, including protein functions, protein families, lipid classifications, lipid-protein binding affinities, membrane association type, and atomic structures. Accessible via a publicly availab

SUBMITTER: Yang LY 

PROVIDER: S-EPMC11618342 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature